We have discovered that a human enzyme long known to have one function has an entirely different function in a certain case. For the scientifically adventurous designers here is a potential caption for the figure we want:
"Human OGT is responsible for the O-GlcNAcylation of serines and threonines in many nuclear and cytoplasmic proteins. Here, Capotosti et al. find that OGT also possesses proteolytic activity as it activates the epigenetic cell-cycle regulator HCF-1 by catalyzing its proteolytic maturation. These results reveal a new property of OGT like a new blade of a pocketknife."
Being from Switzerland (but not Swiss!), we have an idea of a multi-purpose Swiss Army knife in which we are revealing a new function (for example a new blade). So the idea could be a pocketknife with two "blades" open: a bottle/can opener for one function and a knife blade for the new function we have discovered. The knife could be labeled "OGT". We want something simple but artistic input is OK!
The magazine cover has a template, see: http://download.cell.com/images/edi…mplate.tif
Examples of previous covers are at http://www.cell.com/archive?year=2010 .
The instructions are at http://www.cell.com/coversubmissions .
We have a tight deadline. We need to give a preliminary proposal by Monday January 10, after which, if we are selected, we may have time to refine things.